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Activated by the antibiotic rifampicin and numerous plant metabolites, including hyperforin, guggulipid, colupulone, and isoflavones. Response to certain ligands is species-distinct. Activated by Obviously transpiring steroids, such as pregnenolone and progesterone. Binds to the reaction ingredient during the promoters of the CYP3A4 and ABCB1/MDR1